Big Endothelin-1 (1-38), human

大内皮素-1 (1-38)是内皮素1的前体。通过内皮素转化酶(ECE)的活性，大内皮素-1被裂解产生内皮素-1。大内皮素-1在体外可被糜酶水解生成内皮素1 (1-21)。内皮素是内皮衍生的血管收缩肽。H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH (Disulfide bridge: 1-15 and 3-11)