[Cys(HiLyte™ Fluor 647 C2 maleimide)]-Exendin-4

这种肽是HiLyte Fluor 647标记的Extendin-4 (Ex/Em=650 nm/675 nm)。在肽的N-末端添加了半胱氨酸残基，染料通过半胱氨酸巯基部分与该半胱氨酸结合。胰高血糖素样肽1 (GLP-1)受体的激动剂Exendin-4诱导食物摄入后胰岛素的释放。Exendin-4与GLP-1有53%的序列同源性。Exendin-4来源于吉拉怪物Heloderma，在血浆中比GLP-1具有更长的半衰期，从而使其成为更有效的促胰岛素剂。H-Cys(Hilyte™ Fluor 647 C2 maleimide)-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2，分子量5486.4